Hemostatic effect of normal platelet transfusion in severe von Willebrand disease patients.

摘要: Platelet von Willebrand factor (vWF) has been suggested to play an important role in the hemostatic process. Clinical and experimental data indicate that bleeding time (BT) platelet-vessel wall interaction cannot be normalized unless defect of platelet vWF is also corrected. We have examined effect normal concentrate transfusion 1 hour after cryoprecipitate infusion five type III disease (vWD) patients. The attained circulating levels ristocetin cofactor, antigen, VIII activity. In two patients, did not modify BT (greater than 30 minutes), whereas remaining three patients was only partially corrected (from greater 12, 18, 21 minutes). However, immediate completely four cases, one case it shortened 8.30 minutes (n = 3 8 perfusion study, resulted a slight increase deposition (surface coverage range: 2.4% 11.3%), elicited more marked improvement (range: 8.2% 26.4%; P less .02 v post- cryoprecipitate). These results suggest vivo supporting interaction. They give support occasional addition for control serious episodes resistant severe vWD