Microsomal mixed-function oxidase activity and senescence—II. In vivo and in vitro hepatic drug metabolism in rats of different ages following partial hepatectomy

摘要: Abstract The duration of hexobarbital hypnosis was determined in CFN male rats different ages, and hexobarbital-induced sleep time found to increase with advancing age. Partial hepatectomies were then performed on the rodents, vitro zoxazolamine hydroxylase activity decline senescent rats, thereby confirming previous studies. Identical experimental parameters after restoration excised liver mass. increased for animals all while remained unchanged. Thus, rate hepatic drug metabolism old not presence newly generated cells. These results are consistent hypothesis that age-related alterations mixed-function oxidase system a result primary aging changes cells themselves, but compensatory resulting from other tissues.