Tumor-antigen 4. Its immunohistochemical distribution and tissue and serum concentrations in squamous cell carcinoma of the lung and esophagus

摘要: The immunohistochemical distribution and concentrations of tumor-antigen 4 (TA-4) in tissues serum were determined patients with benign malignant diseases, including 27 squamous cell carcinoma (SCC; 15 the lung 12 esophagus). Tumor-antigen immunoreactivity was present cytoplasm many SCC tissues, especially hyperparakeratotic region, differentiated cells intermediate layer normal epithelia various organs, but not those other types cancers or pulmonary diseases. Consistent results immunostaining, TA-4 lung, esophagus, much higher than cancer SCC, submandibular gland tissues. concentration tissue tended to increase increasing grades differentiation. Serum elevated no These indicate that is an antigen related differentiation tumor can release a large amount into circulation whereas cannot.