Acellular Pertussis Vaccine Components: Today and Tomorrow.
作者： Kalyan K Dewan , Bodo Linz , Susan E DeRocco , Eric T Harvill , None
关键词:
摘要: Pertussis is a highly communicable acute respiratory infection caused by Bordetella pertussis. Immunity not lifelong after natural or vaccination. outbreaks occur cyclically worldwide and effective vaccination strategies are needed to control disease. Whole-cell pertussis (wP) vaccines became available in the 1940s but have been replaced many countries with acellular (aP) vaccines. This review summarizes disease epidemiology before introduction of wP aP vaccines, discusses rationale clinical implications for antigen inclusion provides an overview novel vaccine aimed at better combating future.
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