Concentration-dependent radiosensitizing effect of docetaxel in esophageal squamous cell carcinoma cells.

摘要: Taxanes, paclitaxel and docetaxel (DTX) are anticancer agents that exhibit cytotoxicity by inhibiting microtubule polymerization. They enhance the radiosensitivity of various cancers blocking cell cycle in most radiosensitive G2/M phase. Recently, taxanes have been reported to different mechanisms action depending on dose intensity. However, mechanism radio-enhancing effect DTX relation drug intensity is not clearly understood. In present study, we experimentally investigated effects concentrations against esophageal squamous cancer (ESCC); KES cells were used for vitro confirmation effective administration schedule chemoradiotherapy involving ESCC. enhanced radiation killing a concentration-dependent manner cells. High cytotoxic (>10 nM) strongly radiosensitivity. Low (<1 did showed inducing DNA double strand breaks apoptosis after irradiation. high induced G0/G1 phase arrest, respectively Cells treated with exhibited nuclear aggregation associated apoptotic change. contrast, low displayed multi-nucleation or unequal division. conclusion, enhancement ESCC was demonstrated, even using nanomolar effect. has its concentration. Therefore, weekly might effectively treatment