Methods, compositions, and kits for treating pain and pruritis

摘要: The invention features a method for inhibiting one or more voltage-gated ion channels in cell by contacting the with (i) first compound that activates channel-forming receptor is present on nociceptors and/or pruriceptors; and (ii) second inhibits when applied to internal face of but does not substantially inhibit said external channels, wherein capable entering pruriceptors through activated. also quarternary amine derivative other permanently transiently charged channels.