Vitamin A deficiency induces a decrease in EEG delta power during sleep in mice

摘要: Recent report (Maret, S., Franken, P., Dauvilliers, Y., Ghyselinck, N.B., Chambon, Tafti, M., 2005. Retinoic acid signaling affects cortical synchrony during sleep. Science 310, 111-113.) has suggested that vitamin A (retinol and its derivatives) is genetically involved in the electroencephalogram (EEG) delta oscillation However, this finding not yet been confirmed by other studies. In study, we attempted to record sleep EEG behavior, quantify striatal monoamines mice fed a A-deficient (VAD) diet for 4 weeks, order clarify linkage between A. VAD demonstrated significant decrease power of EEG. 6-h deprivation caused recovery level similar control. also spontaneous activity throughout 24-h period. Furthermore, dihydroxyphenylacetic acid, metabolite dopamine, was decreased significantly tissue mice. Our present results suggest deficiency causes attenuation NREM activity. These attenuations may be related alteration dopaminergic function.