Effect of FK506 ointment (Protopic) on rat skin allograft model.

摘要: Abstract Objective FK-506 (tacrolimus) is a well known immunosuppressive agent used to prevent allograft rejection. The need for chronic immunosuppression and the consequent harmful systemic effects preclude use of tissue as routine surgical reconstructive option. This study assessed ointment (Protopic) therapy versus subcutaneous injection (Prograf) on rat skin graft model. Methods Donor Wistar dorsal was grafted recipient Sprague-Dawley rats. Animals groups were divided into 2 groups: Group I treated with intravenous FK-506, group II weeks after surgery. Graft appearance challenges assessed. Results FK506 could prolong median survival time (16.7 days) compared (15.8). Hematoxylin-eosin staining performed allo-skin biopsy samples obtained from both animals at revealed moderate degree rejection accompanied by mixed lymphocyte infiltration. Tacrolimus mean blood levels much lower in ( Conclusions Immunosuppressive has similar effect it be useful prevention