Hypertrophy and neuron loss: structural changes in sheep SCG induced by unilateral sympathectomy.

摘要: Recently, superior cervical ganglionectomy has been performed to investigate a variety of scientific topics from regulation intraocular pressure suppression lingual tumour growth. Despite these recent advances in our understanding the functional mechanisms underlying ganglion (SCG) growth and development after surgical ablation, there still exists need for information concerning quantitative nature relationships between removed SCG its remaining contralateral modified innervation territory. To this end, using design-based stereological methods, we have investigated structural changes induced by unilateral sheep at three distinct timepoints (2, 7 12 weeks) surgery. The effects time, lateral (left-right) differences, were examined two-way analyses variance paired t-tests. Following removal left SCG, main findings were: (i) right was bigger shorter survival times, i.e. 74% 2 weeks, 55% weeks no increase (ii) surgery, contained fewer neurons (no decrease 6% 17% (iii) also larger magnitude grew substantially with time rise 77% 215% weeks). Interaction ganglionectomy-induced significant volume mean perikaryal volume. These show that profound on ganglion. For future investigations, it would be interesting examine interaction SCGs their targets ganglionectomy. Is imbalance sizes territories milieu which morphoquantitative changes, particularly neuron number, occur? Mechanistically, how those arise? Are any grounds believing ganglionectomy-triggered cross-innervation neuroplasticity?