The Predict-IV project: Towards predictive toxicology using in vitro techniques

P. Bellwon, G.L. Truisi, F.Y. Bois, A. Wilmes, T. Schmidt, C.C. Savary, C. Parmentier, P.G. Hewitt, O. Schmal, R. Josse, L. Richert, A. Guillouzo, S.O. Mueller, P. Jennings, E. Testai, W. Dekant, Kinetics and dynamics of cyclosporine A in three hepatic cell culture systems Toxicology in Vitro. ,vol. 30, pp. 62- 78 ,(2015) , 10.1016/J.TIV.2015.07.016

Nynke I. Kramer, Emma Di Consiglio, Bas J. Blaauboer, Emanuela Testai, Biokinetics in repeated-dosing in vitro drug toxicity studies Toxicology in Vitro. ,vol. 30, pp. 217- 224 ,(2015) , 10.1016/J.TIV.2015.09.005

Jos G. Bessems, George Loizou, Kannan Krishnan, Harvey J. Clewell, Camilla Bernasconi, Frederic Bois, Sandra Coecke, Eva-Maria Collnot, Walter Diembeck, Lucian Romeo Farcal, Liesbeth Geraets, Ursula Gundert-Remy, Nynke Kramer, Gabriele Küsters, Sofia B. Leite, Olavi R. Pelkonen, Klaus Schröder, Emanuela Testai, Iwona Wilk-Zasadna, José-Manuel Zaldívar-Comenges, PBTK modelling platforms and parameter estimation tools to enable animal-free risk assessment Regulatory Toxicology and Pharmacology. ,vol. 68, pp. 119- 139 ,(2014) , 10.1016/J.YRTPH.2013.11.008

Davide Germano, Marianne Uteng, Francois Pognan, Salah-Dine Chibout, Armin Wolf, Determination of liver specific toxicities in rat hepatocytes by high content imaging during 2-week multiple treatment. Toxicology in Vitro. ,vol. 30, pp. 79- 94 ,(2015) , 10.1016/J.TIV.2014.05.009

Germaine L. Truisi, Emma Di Consiglio, Céline Parmentier, Camille C. Savary, Giuliana Pomponio, Frederic Bois, Birthe Lauer, Rozenn Jossé, Philip G. Hewitt, Stefan O. Mueller, Lysiane Richert, André Guillouzo, Emanuela Testai, Understanding the biokinetics of ibuprofen after single and repeated treatments in rat and human in vitro liver cell systems Toxicology Letters. ,vol. 233, pp. 172- 186 ,(2015) , 10.1016/J.TOXLET.2015.01.006

Jessica J.W. Broeders, Céline Parmentier, Germaine L. Truisi, Rozenn Jossé, Eliane Alexandre, Camille C. Savary, Philip G. Hewitt, Stefan O. Mueller, André Guillouzo, Lysiane Richert, Jan C.H. van Eijkeren, Joop L.M. Hermens, Bas J. Blaauboer, Biokinetics of chlorpromazine in primary rat and human hepatocytes and human HepaRG cells after repeated exposure. Toxicology in Vitro. ,vol. 30, pp. 52- 61 ,(2015) , 10.1016/J.TIV.2014.08.012

Jérémy Hamon, Maria Renner, Masoud Jamei, Arno Lukas, Annette Kopp-Schneider, Frédéric Y. Bois, Quantitative in vitro to in vivo extrapolation of tissues toxicity Toxicology in Vitro. ,vol. 30, pp. 203- 216 ,(2015) , 10.1016/J.TIV.2015.01.011

Giuliana Pomponio, Camille C. Savary, Céline Parmentier, Frederic Bois, André Guillouzo, Luca Romanelli, Lysiane Richert, Emma Di Consiglio, Emanuela Testai, In vitro kinetics of amiodarone and its major metabolite in two human liver cell models after acute and repeated treatments Toxicology in Vitro. ,vol. 30, pp. 36- 51 ,(2015) , 10.1016/J.TIV.2014.12.012

P. Bellwon, M. Culot, A. Wilmes, T. Schmidt, M.G. Zurich, L. Schultz, O. Schmal, A. Gramowski-Voss, D.G. Weiss, P. Jennings, A. Bal-Price, E. Testai, W. Dekant, Cyclosporine A kinetics in brain cell cultures and its potential of crossing the blood-brain barrier. Toxicology in Vitro. ,vol. 30, pp. 166- 175 ,(2015) , 10.1016/J.TIV.2015.01.003

Lydia Aschauer, Alice Limonciel, Anja Wilmes, Sven Stanzel, Annette Kopp-Schneider, Philip Hewitt, Arno Lukas, Martin O. Leonard, Walter Pfaller, Paul Jennings, Application of RPTEC/TERT1 cells for investigation of repeat dose nephrotoxicity: A transcriptomic study Toxicology in Vitro. ,vol. 30, pp. 106- 116 ,(2015) , 10.1016/J.TIV.2014.10.005