Solubility Measurement and Various Solubility Parameters of Glipizide in Different Neat Solvents.
作者： Mohd Abul Kalam , Aws Alshamsan , Musaed Alkholief , Ibrahim A Alsarra , Raisuddin Ali
关键词:
摘要: Glipizide (GLZ) is an oral hypoglycemic agent, which a weakly aqueous soluble drug. The solubility values of GLZ in various neat solvents are scarce the literature. Hence, 12 different solvents, namely, "water, methanol, ethanol, isopropanol (IPA), 1-butanol, 2-butanol, ethylene glycol (EG), propylene (PG), poly(ethylene glycol)-400 (PEG-400), ethyl acetate (EA), dimethyl sulfoxide (DMSO), and Transcutol-HP (THP)", at "T = 298.2-318.2 K" "p 0.1 MPa" was measured. recorded solubilities were correlated by "van't Hoff Apelblat models" using root-mean-square deviation (RMSD). overall RMSD obtained as 1.21 1.40% for "Apelblat van't models", respectively. Different parameters all studied materials including drug solvent calculated to find best GLZ. (expressed mole fraction) have been found highest DMSO (2.81 × 10-2), followed THP, EA, IPA, PEG-400, PG, EG, water (1.98 10-4) 318.2 K". All investigated very close DMSO. "Apparent thermodynamic analysis" showed "endothermic entropy-driven dissolution" solvents. molecular interactions GLZ-DMSO compared other combinations. Overall, has considered solubilization
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