Process for preparing dithiophosphate oligonucleotide analogs via nucleoside thiophosphoramidite intermediates
作者： Nassar Farschtschi , David Gorenstein
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摘要: A method for synthesis of oligonucleotide analogs having dithiophosphate internucleosidic linkages is described. Monohalohydrocarbylthiophosphoramidites are utilized to prepare nucleoside thiophosphoramidite intermediates which activated coupling with tetrazole catalysts. Sulfur oxidation and dehydrocarbylation the coupled thiophosphite provide achiral linkages.
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