作者: YASUTOMI NISHIZUKA , YOSHIMI TAKAI , AKIRA KISHIMOTO , USHIO KIKKAWA , KOZO KAIBUCHI
DOI: 10.1016/B978-0-12-571140-1.50012-8
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摘要: Publisher Summary This chapter discusses the activation and properties of protein kinase C signal-induced breakdown inositol phospholipids that is directly linked to C. Under resting conditions in most tissues, present as an inactive form presumably soluble cytosol or loosely bound membranes. It activated by tight association with membranes a signal-dependent manner. The enzyme requires Ca2+ phospholipid for its activation. turnover sign transmembrane control cellular functions proliferation through Both play diverse roles biological regulation, precise targets well those many tissues will be clarified further investigations. Inositol trisphosphate, which one products phosphatidylinositol bisphosphate cleavage, recently proposed possible candidate intracellular mediator Ca2+.