Hydrolases in Organic Synthesis: Regio- and Stereoselective Biotransformations

摘要: 1 Introduction. 2 Designing Enantioselective Reactions. 2.1 Kinetic Resolutions. 2.2 Asymmetric Syntheses. 3 Choosing Reaction Media: Water and Organic Solvents. 3.1 Hydrolysis in Water. 3.2 Transesterifications Condensations 3.3 Other Media. 3.4 Immobilization. 4 Protein Sources Optimization of Biocatalyst Performance. 4.1 Accessing Biodiversity. 4.2 Creating Improved Biocatalysts. 4.3 Catalytic Promiscuity Hydrolases. 5 Lipases Esterases. 5.1 Availability, Structures Properties. 5.2 Survey Lipase-Catalyzed 5.3 Chemo-and Regioselective 5.4 Reactions Catalyzed by 6 Proteases Amidases. 6.1 Occurrence Availability 6.2 General Features Subtilisin, Chymotrypsin, 6.3 6.4 Protease-and Amidase-Catalyzed 7 Phospholipases. 7.1 Phospholipase A1. 7.2 A2. 7.3 C. 7.4 D. 8 Epoxide 8.1 8.2 Mammalian 8.3 Microbial 9 Nitriles. 9.1 9.2 Mild Conditions. 9.3 Dinitriles. 9.4 10 10.1 Glycosidases. 10.2 Haloalcohol Dehalogenases. 10.3 Phosphotriesterases. Abbreviations. References. Index.