Regioselective synthesis of 1,2,4-trisubstituted imidazole from a mechanistic and synthetic prospective
作者： Suman Punia , Vikas Verma , Devinder Kumar , Gurjaspreet Singh , Subash C. Sahoo
DOI: 10.1080/00397911.2020.1712608
关键词:
摘要: AbstractThe highly substituted 1,2,4-trisubtituted imidazole was regioselectively synthesized via base mediated domino reaction of amidine scaffold with phenacyl bromide followed by in situ N-alkyl...
sci-hub.se 参考文章(20)
Wei Yue, Hu Wang, Synthesis and biological evaluation of N -hydroxybenzimidazoles as potential anticancer agents targeting human lactate dehydrogenase A Monatshefte Fur Chemie. ,vol. 146, pp. 2079- 2086 ,(2015) , 10.1007/S00706-015-1513-9
Bakr F. Abdel-Wahab, Ghada E.A. Awad, Farid A. Badria, Synthesis, antimicrobial, antioxidant, anti-hemolytic and cytotoxic evaluation of new imidazole-based heterocycles. European Journal of Medicinal Chemistry. ,vol. 46, pp. 1505- 1511 ,(2011) , 10.1016/J.EJMECH.2011.01.062
Kamleshwar Tiwari, Pankaj Kumar Verma, Shyam Babu Singh, Jagdamba Singh, Synthesis of Imidazo[2,1-b]-1,3,4-thiadiazoles in DABCO as an Efficient and Recyclable Catalyst Synthetic Communications. ,vol. 42, pp. 3021- 3030 ,(2012) , 10.1080/00397911.2011.574329
N.C. Desai, A.S. Maheta, K.M. Rajpara, V.V. Joshi, H.V. Vaghani, H.M. Satodiya, Green synthesis of novel quinoline based imidazole derivatives and evaluation of their antimicrobial activity Journal of Saudi Chemical Society. ,vol. 18, pp. 963- 971 ,(2014) , 10.1016/J.JSCS.2011.11.021
Amir Assadieskandar, Mohsen Amini, Marjan Salehi, Hamid Sadeghian, Maliheh Alimardani, Amirhossein Sakhteman, Hamid Nadri, Abbas Shafiee, Synthesis and SAR study of 4,5-diaryl-1H-imidazole-2(3H)-thione derivatives, as potent 15-lipoxygenase inhibitors. Bioorganic & Medicinal Chemistry. ,vol. 20, pp. 7160- 7166 ,(2012) , 10.1016/J.BMC.2012.09.050
Marco Fantini, Mirko Rivara, Valentina Zuliani, Christopher L. Kalmar, Federica Vacondio, Claudia Silva, Aparna R. Baheti, Natasha Singh, Ellen C. Merrick, Ravi S. Katari, Giuseppe Cocconcelli, Chiara Ghiron, Manoj K. Patel, 2,4(5)-diarylimidazoles as inhibitors of hNaV1.2 sodium channels: pharmacological evaluation and structure-property relationships. Bioorganic & Medicinal Chemistry. ,vol. 17, pp. 3642- 3648 ,(2009) , 10.1016/J.BMC.2009.03.067
Dong Tang, Ping Wu, Xiang Liu, Yong-Xin Chen, Shuai-Bo Guo, Wen-Lin Chen, Jia-Gen Li, Bao-Hua Chen, None, Synthesis of multisubstituted imidazoles via copper-catalyzed [3 + 2] cycloadditions. Journal of Organic Chemistry. ,vol. 78, pp. 2746- 2750 ,(2013) , 10.1021/JO302555Z
Bryan Li, Charles K.-F. Chiu, Richard F. Hank, Jerry Murry, Joshua Roth, Harry Tobiassen, An Optimized Process for Formation of 2,4-Disubstituted Imidazoles from Condensation of Amidines and α-Haloketones Organic Process Research & Development. ,vol. 6, pp. 682- 683 ,(2002) , 10.1021/OP025552B
Yuanxiang Wang, Brendan Frett, Hong-yu Li, Efficient access to 2,3-diarylimidazo[1,2-a]pyridines via a one-pot, ligand-free, palladium-catalyzed three-component reaction under microwave irradiation. Organic Letters. ,vol. 16, pp. 3016- 3019 ,(2014) , 10.1021/OL501136E
Rahul Mishra, Swastika Ganguly, Imidazole as an anti-epileptic: an overview Medicinal Chemistry Research. ,vol. 21, pp. 3929- 3939 ,(2012) , 10.1007/S00044-012-9972-6