Involvement of Histamine and RhoA/ROCK in Penicillin Immediate Hypersensitivity Reactions.

摘要: The mechanism of penicillin immediate hypersensitivity reactions has not been completely elucidated. These are generally considered to be mediated by IgE, but penicillin-specific IgE could detected in most cases. This study demonstrated that was able cause vascular hyperpermeability a mouse model mimicking clinical symptoms reactions. first exposure also induced edema and exudative ears lungs mice dose-dependent manner. Vasodilation noted microvessels ears. were unlikely immune-mediated reactions, because no produced. Furthermore, treatment directly elicited rapid histamine release. Penicillin led F-actin reorganization human umbilical vein endothelial cells increased the permeability monolayer. Activation RhoA/ROCK signaling pathway observed after with penicillin. Both an anti-histamine agent ROCK inhibitor attenuated mice. presents novel suggests potential preventive approach against these