Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 – Part I

摘要: ABSTRACTIntroduction: TrkA/B/C receptor activation supports growth, survival, and differentiation of discrete neuronal populations during development, adult life, ageing but also plays numerous roles in human disease onset progression. Trk-specific inhibitors have therapeutic applications cancer pain thus constitute a growing area interest oncology neurology. There has been substantial growth the number structural classes Trk industrial entrants to inhibitor field over past six years.Areas covered: In Part II this two-part review, discussion recent patent literature covering family is continued from I clinical research with considered.Expert opinion: molecularly targeted for decade resulting progressive evolution structurally diversified arising scaffold hopping HTS efforts. Correspondingly, there number...