Gene-Environment Interactions Relevant to Estrogen and Risk of Breast Cancer: Can Gene-Environment Interactions Be Detected Only among Candidate SNPs from Genome-Wide Association Studies?

摘要: In this study we aim to examine gene-environment interactions (GxEs) between genes involved with estrogen metabolism and environmental factors related exposure. GxE analyses were conducted 1970 Korean breast cancer cases 2052 controls in the case-control study, Seoul Breast Cancer Study (SEBCS). A total of 11,555 SNPs from 137 candidate included eight established factors. replication test was by using an independent population Association Consortium (BCAC), 62,485 Europeans 9047 Asians. The tests performed two-step methods GxEScan software. Two found SEBCS. first interaction shown rs13035764 NCOA1 age at menarche GE|2df model (p-2df = 1.2 × 10-3). before 14 years old associated high risk cancer, higher when subjects had homozygous minor allele G. second rs851998 near ESR1 height 1.1 10-4). Height taller than 160 cm a increased added. findings not replicated BCAC. These results would suggest specificity Koreans for risk.