Modulation of Orthographic Decoding by Frontal Cortex

摘要: Opinions are divided on whether word reading processes occur in a hierarchical, feedforward fashion or within an interactive framework. To critically evaluate these competing theories, we recorded electrocorticographic (ECoG) data from 15 human patients with intractable epilepsy during completion task and evaluated brain network dynamics across individuals. We used novel technique of analyzing multihuman ECoG recordings to identify cortical regions most relevant processing lexical information. The mid fusiform gyrus showed the strongest, earliest response after stimulus onset, whereas activity was maximal frontal, dorsal lateral prefrontal, sensorimotor toward articulation onset. interregional functional connectivity, electrodes situated over specific interest were fit into linear multivariate autoregressive (MVAR) models. Spectral characteristics MVAR models precisely reveal timing magnitude information flow between localized regions. This is first application for developing comprehensive account interactions dataset. Our findings revealed both top-down bottom-up influences higher-level language areas gyrus. thus challenge strictly views suggest that orthographic modulated by prefrontal via SIGNIFICANCE STATEMENT Word critical part everyday life. When ability read disrupted, it can lead learning disorders, as well emotional academic difficulties. neural mechanisms underlying not understood due limitations spatial temporal specificity prior studies. research analyzed sensors implanted directly surface brains while individuals performed task. infer how communicate reading. original results improve upon current be develop treatment plans disabilities.