The issues and tentative solutions for contrast-enhanced magnetic resonance imaging at ultra-high field strength

摘要: Magnetic resonance imaging (MRI) performed at ultra-high field strengths beyond 3 Tesla (T) has become increasingly prevalent in research and preclinical applications. As such, the inevitable clinical implementation of such systems lies on horizon. The major benefit MRI is markedly increased signal-to-noise ratios achievable, enabling acquisition MR images with simultaneously greater spatial temporal resolution. However, higher than T, efficacy Gd(III)-based contrast agents diminished due to decreased r1 relaxivity, somewhat limiting vasculature contrast-enhanced tumors. There have been extensive efforts design new high relaxivities based macromolecular compounds or nanoparticles; however, these not yet proven. aim this review article provide an overview basic principles enhancement processes highlight main factors influencing relaxivity. In addition, challenges opportunities for will be explored. Various approaches development effective agent molecules that are suitable a broad spectrum applied discussed context current literature. WIREs Nanomed Nanobiotechnol 2014, 6:559–573. doi: 10.1002/wnan.1291 For further resources related article, please visit website. Conflict interest: authors declared no conflicts interest article.