Screening of amphetamine/methamphetamine and their derivatives in urine using FPIA and Triage 8 and the Scope and limits of a subsequent identification by means of the REMEDi HS system.

摘要: This study describes screening and identifying amphetamines, methamphetamines, their derivatives in urine using immunochemical (Triage™8, FPIA) chromatographic techniques (REMEDi™ HS). Amphetamines, MDMA (3,4-methylenedioxymethamphetamine), MDA (3,4-methylenedioxyamphetamine), MDE (3,4-methylenedioxyethylamphetamine), MBDB (N-methyl-1-(3,4-methylenedioxyphenyl)-2-butanamine), BDB (3,4-(methylenedioxyphenyl)-2-butanamine), PMA (4-methoxyamphetamine), DOM (2,5-dimethyloxy-4-methylamphetamine), DOB (4-bormo-2,5-dimethyloxyamphetamine), amphetaminil, pholedrine, fenfluramine, amfepramone were subjected to a comparative study. For this, the substances analyzed determine specific threshold concentration for positive detection Triage test limit of FPIA results compared. Furthermore, capabilities more detailed analysis with REMEDi system studied. HPLC was able produce information on single drugs main metabolites found sample danger false-positive or false-negative greatly minimized.