Clustering, duplication and chromosomal distribution of mouse SINE retrotransposons

摘要: We analyzed potential mechanisms determining chromosomal distributions of the mouse B1 and B2 non-LTR retrotransposons, also known as SINE elements. report that young SINEs are underrepresented on chromosome X relative to autosomes, which is consistent with their integration in male germ lines. As age elements progresses, densities increase autosomal densities, possibly due differences ectopic recombination rates between autosomes. Furthermore, unlike human Alus tend be integrated outside Alu-dense regions, found mostly SINE-rich clusters. The B1- or B2-rich clusters more likely contain duplicated than B2-poor regions. present evidence indicating association intra-chromosomal segmental duplications. No such was inter-chromosomal propose accumulation observed GC-rich regions may excess DNA duplications over deletions gene-rich GC rich.