Mechanism of coralyne-mediated DNA photo-nicking process
作者： Birija Sankar Patro , Rahul Bhattacharyya , Pooja Gupta , Sandip Bandyopadhyay , Subrata Chattopadhyay
DOI: 10.1016/J.JPHOTOBIOL.2019.03.011
关键词:
摘要: Previously, we reported that coralyne and UVA combination sensitized a wide range of human carcinoma cells regardless their p53 status. The induced photosensitization cancer may be clinically attractive, as mutation in the gene is prevalent many types tumors. Coralyne mediated attributable to its ability cause extensive DNA single strand breaks (SSB). However, precise mechanism photo-damage not yet known. present study was aimed understand hitherto unknown coralyne-induced photo-cleavage process. To this end, compared photo-nicking properties berberine, jatrorrhizine coralyne, deciphered involvement photochemical processes photo-nuclease action using absorption electron spin resonance spectroscopy, high performance liquid chromatography mass spectroscopy (MS) techniques conjunction with relevant vitro studies plasmid DNA. In association UVA, but berberine significant nicking via an O2-independent photo-chemical Job's plot our spectrophotometric data suggested one molecule remains intercalated two base pairs (i. e., 1:2) starts forming aggregates beyond molar ratio. by (designated CUVA) primarily caused without any contribution from DNA-intercalated monomer.
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