Frequent c-myc Amplification in High-Grade Dysplasia and Adenocarcinoma in Barrett Esophagus
作者： Mario Sarbia , Jawed Arjumand , Marietta Wolter , Guido Reifenberger , Hansjörg Heep
DOI: 10.1309/MXXH-25N3-UAL2-G7XX
关键词:
摘要: Barrett esophagus (BE) is a condition in which the normal squamous epithelium of replaced by metaplastic columnar epithelium. BE premalignant lesion that represents initial step metaplasia-dysplasia-carcinoma sequence. In present study, amplification proto-oncogene c-myc was determined means differential polymerase chain reaction analysis specialized epithelium, low-grade dysplasia, high-grade and invasive adenocarcinoma obtained microscopic dissection 43 esophagectomy specimens. Amplification found none 29 epithelial specimens, 23 dysplasia 6 24 17 39 Our data indicate late event sequence BE. Furthermore, determination may help identify high-risk patients who would benefit from intensified endoscopic surveillance or immediate treatment.
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