Type I interferons are important co-stimulatory signals during T cell receptor mediated MAIT cell activation

摘要: Abstract Mucosal associated invariant T (MAIT) cells are abundant unconventional which can be stimulated either via their cell receptor (TCR) or by innate cytokines. The MAIT TCR recognises a pyrimidine ligand, derived from riboflavin synthesising bacteria, bound to MR1. In infection, bacteria not only provide the ligand but also co-stimulatory signals, such as Toll-like agonists, that modulate TCR-mediated activation. Recently, type I interferons (T1-IFNs) have been identified contributing cytokine-mediated However, it is unknown whether T1-IFNs role during this study, we investigated of activation MR1 5-amino-6-D-ribitylaminouracil/methylglyoxal (5-A-RU/MG). We found were able boost interferon-γ and granzyme B production in 5-A-RU/MG-stimulated cells. Similarly, influenza virus-induced enhanced An essential regulating was demonstrated. confirmed using liver-derived acted directly on enhance response stimulation. Overall, our findings establish an important immunomodulatory