Pathogenesis of Obesity-Related Chronic Liver Diseases as the Study Case for the Systems Biology
作者： Ancha Baranova , Aybike Birerdinc , Michael Estep , Zobair M. Younossi
DOI: 10.1007/978-1-4419-5797-9_26
关键词:
摘要: To understand human pathology at the system level, one must examine complex milieu of molecular interactions between various cells within body, rather than characteristics isolated cell or cultured cell. However, all over body an understanding pathophysiology particular tissues has lagged behind insights in general biological processes. A “high-throughput revolution” unfolding model clinical science leads to significant increase knowledge describing transcriptome and proteome states diseases, including pathologies liver. Despite seeming accessibility profiling techniques, cautionary approach is necessary interpretation data. There are universal caveats that preclude meta-analysis data collected. Major obstacles heterogeneity samples profiled, imperfect correlation mRNA protein levels, normal variation levels mRNAs corresponding proteins healthy individuals. Nevertheless, a gain NAFLD spectrum diseases reached recently inseparable from accumulated high-throughput projects.
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