Primary γδ Cell Clones Can Be Defined Phenotypically and Functionally as Th1/Th2 Cells and Illustrate the Association of CD4 with Th2 Differentiation

摘要: The division of CD4+ αβ T cells into Th1 and Th2 subsets has become an established important paradigm. respective activities these appear to have profound effects on the course infectious autoimmune diseases. It is believed that specific programs differentiation induce commitment uncommitted Th0 precursor cell or Th2. A component hypothesized be nature MHC-peptide antigen presentation cell. heretofore remained uncertain whether a Th1/Th2 classification likewise defines, at clonal level, γδ cells. Such do not, as general rule, express either CD4 CD8αβ, they not commonly recognize peptide-MHC. In this report, clones are described conform strikingly classification, both by cytokine expression functional in vitro vivo. Provocatively, primary vivo showed strong association phenotype with expression. These results discussed regard immunoregulatory role increasingly emerging for