Association of NOTCH3 Gene Polymorphisms with Ischemic Stroke and Its Subtypes: A Meta-Analysis
作者： Loo Keat Wei , Lyn R. Griffiths , Irene Looi , Cheah Wee Kooi , None
关键词:
摘要: Background and objectives: NOTCH3 gene variations play a significant role in cerebral autosomal dominant arteriopathy with subcortical infarcts leukoencephalopathy (CADASIL). However, the of polymorphisms risk ischemic stroke, its subtypes such as atherothrombotic or lacunar strokes, remains unclear. Aims: Hence, we carried out meta-analysis to examine whether rs1043994, rs1044009 rs3815188 are associated stroke major subtypes. Materials Methods: All relevant studies were systematically screened meta-analyzed using Review Manager (Revman) version 5.3. The strength association between measured odds ratios 95% confidence intervals, under different genetic models. Results: A total ten identified, five which considered rs1043994 (2077 cases/2147 controls), (2315 cases/3053 nine (2819 cases/2769 controls). These for their risk. Four (874 cases/2002 controls) polymorphism three (643 cases/1552 Three (1013 cases/1972 results showed lack all studied (i.e., lacunar). Conclusions: not significantly (p < 0.05).
mdpi.com 
sci-hub.se 参考文章(25)
Jeremy T. Baeten, Brenda Lilly, Differential Regulation of NOTCH2 and NOTCH3 Contribute to Their Unique Functions in Vascular Smooth Muscle Cells. Journal of Biological Chemistry. ,vol. 290, pp. 16226- 16237 ,(2015) , 10.1074/JBC.M115.655548
Owen A Ross, Alexandra I Soto-Ortolaza, Michael G Heckman, Christophe Verbeeck, Daniel J Serie, Sruti Rayaprolu, Stephen S Rich, Michael A Nalls, Andrew Singleton, Rita Guerreiro, Emma Kinsella, Zbigniew K Wszolek, Thomas G Brott, Robert D Brown Jr, Bradford B Worrall, James F Meschia, None, NOTCH3 Variants and Risk of Ischemic Stroke PLoS ONE. ,vol. 8, pp. e75035- ,(2013) , 10.1371/JOURNAL.PONE.0075035
Bing-Wen Soong, Yi-Chu Liao, Pang-Hsien Tu, Pei-Chien Tsai, I-Hui Lee, Chih-Ping Chung, Yi-Chung Lee, A homozygous NOTCH3 mutation p.R544C and a heterozygous TREX1 variant p.C99MfsX3 in a family with hereditary small vessel disease of the brain Journal of the Chinese Medical Association. ,vol. 76, pp. 319- 324 ,(2013) , 10.1016/J.JCMA.2013.03.002
Loo Keat Wei, Heidi Sutherland, Anthony Au, Emily Camilleri, Larisa M Haupt, Siew Hua Gan, Lyn R Griffiths, None, A Potential Epigenetic Marker Mediating Serum Folate and Vitamin B12 Levels Contributes to the Risk of Ischemic Stroke BioMed Research International. ,vol. 2015, pp. 167976- 167976 ,(2015) , 10.1155/2015/167976
Junhao Liu, Kai Sun, Yongyi Bai, Weili Zhang, Xiaojian Wang, Yibo Wang, Hu Wang, Jingzhou Chen, Xiaodong Song, Ying Xin, Zhe Liu, Rutai Hui, Association of three-gene interaction among MTHFR, ALOX5AP and NOTCH3 with thrombotic stroke: a multicenter case-control study. Human Genetics. ,vol. 125, pp. 649- 656 ,(2009) , 10.1007/S00439-009-0659-0
TOSHIKI MIZUNO, MASAHIRO MAKINO, YASUHIRO FUJIWARA, KENJI NAKAJIMA, Lack of association between NOTCH3 gene polymorphism and cerebrovascular disease in Japanese patients. Annals of the New York Academy of Sciences. ,vol. 977, pp. 252- 257 ,(2002) , 10.1111/J.1749-6632.2002.TB04823.X
JAKOB GRANILD-JENSEN, UFFE BIRK JENSEN, MARIANNE SCHWARTZ, UFFE STENDER HANSEN, Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy resulting in stroke in an 11-year-old male. Developmental Medicine & Child Neurology. ,vol. 51, pp. 754- 757 ,(2009) , 10.1111/J.1469-8749.2008.03241.X
Anne Joutel, Fréderic Andreux, Swann Gaulis, Valérie Domenga, Michaelle Cecillon, Nicole Battail, Nadia Piga, Françoise Chapon, Catherine Godfrain, Elisabeth Tournier-Lasserve, The ectodomain of the Notch3 receptor accumulates within the cerebrovasculature of CADASIL patients Journal of Clinical Investigation. ,vol. 105, pp. 597- 605 ,(2000) , 10.1172/JCI8047
H.-H. Kim, S. I. Savitz, J. K. Liao, S. Salomone, C. Ayata, M. A. Moskowitz, S. Artavanis-Tsakonas, J. F. Arboleda-Velasquez, Z. Zhou, H. K. Shin, A. Louvi, Linking Notch signaling to ischemic stroke Proceedings of the National Academy of Sciences of the United States of America. ,vol. 105, pp. 4856- 4861 ,(2008) , 10.1073/PNAS.0709867105
Keat Wei Loo, Siew Hua Gan, None, Burden of stroke in Malaysia International Journal of Stroke. ,vol. 7, pp. 165- 167 ,(2012) , 10.1111/J.1747-4949.2011.00767.X