Immortalization of precursor cells from the mammalian CNS

摘要: Recent studies show that the nervous system contains many molecularly distinct cell types. Clonal marking experiments demonstrate different types in some areas of CNS are products a multipotential stem cell. The factors controlling differentiation vertebrate precursor cells would be more accessible to molecular analysis if lines with properties could established. Here we expressing an antigenic marker specific for major brain population can established from rat cerebellum. We express precursor, neuronal or glial depending on growth conditions. This work supports view Rat 401 and differentiate into either properties. Cell capable should useful defining signaling systems generating brain.