Synthesis: A constructive debate.

作者: Jay D. Keasling , Abraham Mendoza , Phil S. Baran

DOI: 10.1038/492188A

关键词:

摘要: Synthetic chemistry has long been used to prepare useful compounds — especially those that are hard obtain from natural sources. But synthetic biology is coming of age as an alternative strategy. A biologist and two chemists debate the merits their fields' prowess.

参考文章(11)
Mark G Charest, Christian D Lerner, Jason D Brubaker, Dionicio R Siegel, Andrew G Myers, A Convergent Enantioselective Route to Structurally Diverse 6-Deoxytetracycline Antibiotics Science. ,vol. 308, pp. 395- 398 ,(2005) , 10.1126/SCIENCE.1109755
Nancy Acton, Ronald J. Roth, On the conversion of dihydroartemisinic acid into artemisinin Journal of Organic Chemistry. ,vol. 57, pp. 3610- 3614 ,(1992) , 10.1021/JO00039A020
Heidi Ledford, Complex synthesis yields breast-cancer therapy Nature. ,vol. 468, pp. 608- 609 ,(2010) , 10.1038/468608A
J. B. Siegel, A. Zanghellini, H. M. Lovick, G. Kiss, A. R. Lambert, J. L. St.Clair, J. L. Gallaher, D. Hilvert, M. H. Gelb, B. L. Stoddard, K. N. Houk, F. E. Michael, D. Baker, Computational design of an enzyme catalyst for a stereoselective bimolecular Diels-Alder reaction Science. ,vol. 329, pp. 309- 313 ,(2010) , 10.1126/SCIENCE.1190239
Abraham Mendoza, Yoshihiro Ishihara, Phil S. Baran, Scalable enantioselective total synthesis of taxanes Nature Chemistry. ,vol. 4, pp. 21- 25 ,(2012) , 10.1038/NCHEM.1196
Eric J. Steen, Yisheng Kang, Gregory Bokinsky, Zhihao Hu, Andreas Schirmer, Amy McClure, Stephen B. del Cardayre, Jay D. Keasling, Microbial production of fatty-acid-derived fuels and chemicals from plant biomass Nature. ,vol. 463, pp. 559- 562 ,(2010) , 10.1038/NATURE08721
Ryan McDaniel, Ron Weiss, Advances in synthetic biology: on the path from prototypes to applications Current Opinion in Biotechnology. ,vol. 16, pp. 476- 483 ,(2005) , 10.1016/J.COPBIO.2005.07.002
Dae-Kyun Ro, Eric M. Paradise, Mario Ouellet, Karl J. Fisher, Karyn L. Newman, John M. Ndungu, Kimberly A. Ho, Rachel A. Eachus, Timothy S. Ham, James Kirby, Michelle C. Y. Chang, Sydnor T. Withers, Yoichiro Shiba, Richmond Sarpong, Jay D. Keasling, Production of the antimalarial drug precursor artemisinic acid in engineered yeast Nature. ,vol. 440, pp. 940- 943 ,(2006) , 10.1038/NATURE04640