Oral delivery of hematopoietic factors

摘要: As a second wave of biopharmaceuticals, oral protein/peptide delivery systems have been studied and applied to hematopoietic factors such as erythropoietin (EPO) granulocyte colony-stimulating factor (G-CSF). Many conventional drug-delivery absorption enhancers, emulsions, liposomes, microcapsules nanocapsules, protein-unfolding technology, protein conjugates, colon technology challenged for the development preparations. Those were designed solve two hurdles: hydrolytic degradation by digestive enzymes poor membrane permeability due their three-dimensional structures. Furthermore, all trials faced hurdle low bioavailability, because dilution spreading an enhancer in gastrointestinal tract reduces effect on factors. To these problems, mucoadhesive patch system (GI-MAPS) was designed.