Prospect of Plasmacytoid Dendritic Cells in Enhancing Anti-Tumor Immunity of Oncolytic Herpes Viruses.

摘要: The major type I interferon-producing plasmacytoid dendritic cells (pDC) surround and infiltrate certain tumors like malignant melanoma, head neck cancer, ovarian breast cancer. presence of pDC in these is associated with an unfavorable prognosis for the patients as long are unstimulated. Upon activation by synthetic Toll-like receptor agonists or viruses, however, develop cytotoxic activities. Viruses have additional advantage to augment activities via lytic replication lesions. These effects turn cold into hotspots, recruiting further immune site inflammation. Activated contribute cross-presentation tumor-associated antigens classical cells, which induce T-cells particular checkpoint inhibitors. modification oncolytic herpes viruses genetic engineering favorably affects this process through enhanced production pro-inflammatory cytokines, curbing tumor blood supply, removal extracellular barriers efficient viral spread. Importantly, vectors may stimulation memory-type adaptive responses presentation tumor-related neo- and/or self-antigens. Eventually, both replication-competent replication-deficient simplex virus 1 (HSV-1) serve vaccine vectors, regression other adjuvant neo-adjuvant situations.