GxE Interactions between FOXO Genotypes and Tea Drinking Are Significantly Associated with Cognitive Disability at Advanced Ages in China
作者： Y. Zeng , H. Chen , T. Ni , R. Ruan , L. Feng
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摘要: Logistic regression analysis based on data from 822 Han Chinese oldest old aged 92+ demonstrated that interactions between carrying FOXO1A-266 or FOXO3-310 FOXO3-292 and tea drinking at around age 60 present time were significantly associated with lower risk of cognitive disability advanced ages. Associations reduced much stronger among carriers the genotypes compared noncarriers, it was reconfirmed by three-way across FOXO genotypes, 60, time. Based prior findings animal human cell models, we postulate intake compounds may activate gene expression, which in turn positively affect function population. Our empirical imply health benefits particular nutritional interventions, including drinking, may, part, depend upon individual genetic profiles.
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sci-hub.se 参考文章(46)
Susan E. Folstein, Marshal F. Folstein, Paul R. McHugh, F. Folstein, A PRACTICAL METHOD FOR GRADING THE COGNITIVE STATE OF PATIENTS FOR THE CLINICIAN ,(2002)
Zeng Yi, Danan Gu, Dudley L Poston, Denese Ashbaugh Vlosky, None, Healthy longevity in China : demographic, socioeconomic, and psychological dimensions Springer. ,(2008)
Kenneth J. Rothman, Epidemiology: An Introduction ,(2002)
Dan G. Blazer, Lyla M. Hernandez, Genes, Behavior, and the Social Environment : Moving Beyond the Nature/Nurture Debate ,(2006)
Marshal F. Folstein, Susan E. Folstein, Paul R. McHugh, “Mini-mental state” Journal of Psychiatric Research. ,vol. 12, pp. 189- 198 ,(1975) , 10.1016/0022-3956(75)90026-6
G.-H. Cui, Y.-H. Yao, R.-F. Xu, H.-D. Tang, G.-X. Jiang, Y. Wang, G. Wang, S.-D. Chen, Q. Cheng, Cognitive impairment using education-based cutoff points for CMMSE scores in elderly Chinese people of agricultural and rural Shanghai China. Acta Neurologica Scandinavica. ,vol. 124, pp. 361- 367 ,(2011) , 10.1111/J.1600-0404.2010.01484.X
Ludmila Pawlikowska, Donglei Hu, Scott Huntsman, Andrew Sung, Catherine Chu, Justin Chen, Alexander H. Joyner, Nicholas J. Schork, Wen-Chi Hsueh, Alexander P. Reiner, Bruce M. Psaty, Gil Atzmon, Nir Barzilai, Steven R. Cummings, Warren S. Browner, Pui-Yan Kwok, Elad Ziv, , Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity. Aging Cell. ,vol. 8, pp. 460- 472 ,(2009) , 10.1111/J.1474-9726.2009.00493.X
Friederike Flachsbart, Amke Caliebe, Rabea Kleindorp, Hélène Blanché, Huberta von Eller-Eberstein, Susanna Nikolaus, Stefan Schreiber, Almut Nebel, Association of FOXO3A variation with human longevity confirmed in German centenarians Proceedings of the National Academy of Sciences of the United States of America. ,vol. 106, pp. 2700- 2705 ,(2009) , 10.1073/PNAS.0809594106
Sang-Ki Park, In-Chul Jung, Won Kyung Lee, Young Sun Lee, Hyoung Kook Park, Hyo Jin Go, Kiseong Kim, Nam Kyoo Lim, Jin Tae Hong, Sun Yung Ly, Seok Seon Rho, A Combination of Green Tea Extract and l-Theanine Improves Memory and Attention in Subjects with Mild Cognitive Impairment: A Double-Blind Placebo-Controlled Study Journal of Medicinal Food. ,vol. 14, pp. 334- 343 ,(2011) , 10.1089/JMF.2009.1374
Sharmila Shankar, Luke Marsh, Rakesh K. Srivastava, EGCG inhibits growth of human pancreatic tumors orthotopically implanted in Balb C nude mice through modulation of FKHRL1/FOXO3a and neuropilin Molecular and Cellular Biochemistry. ,vol. 372, pp. 83- 94 ,(2013) , 10.1007/S11010-012-1448-Y