Norepinephrine Metabolism in Man Using Deuterium Labelling: The Conversion of 4-Hydroxy-3-Methoxyphenylglycol to 4-Hydroxy-3-Methoxymandelic Acid
作者： Göran Mårdh , Birgitta Sjöquist , Erik ÄnggÅrd
DOI: 10.1111/J.1471-4159.1981.TB01716.X
关键词:
摘要: 4-Hydroxy-3-methoxyphenylglycol (HMPG) labelled with three deuterium atoms was used to study the disposition of peripherally administered HMPG. Five healthy men were given an intravenous pulse dose 4.3 mumol HMPG and subsequent plasma urine levels endogenous as well those 4-hydroxy-3-methoxymandelic acid (HMMA, VMA) determined by gas chromatography-mass spectrometry, using selected ion detection. Approximately 40% injected amount deuterium-labelled recovered in HMMA another eliminated conjugates. Thus, formed from norepinephrine either central or peripheral nervous system undergoes both conjugation extensive oxidation.
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