The performance of the alarmin HMGB1 in pediatric diseases: From lab to clinic.

摘要: Introduction The ubiquitously expressed nonhistone nuclear protein high-mobility group box 1 (HMGB1) has different functions related to posttranslational modifications and cellular localization. In the nucleus, HMGB1 modulates gene transcription, replication DNA repair as well determines chromosomal architecture. When post-transcriptional modified is released into extracellular space, it triggers several physiological pathological responses initiates innate immunity through interacting with its reciprocal receptors (i.e., TLR4/2 RAGE). effect of HMGB1-mediated inflammatory activation on systems received increasing attention. now considered be an alarmin participates in multiple inflammation-related diseases. addition, also affects occurrence progression tumors. However, most studies involving have been focused adults or mature animals. Due differences disease characteristics between children adults, necessary clarify role pediatric Methods results Through systematic database retrieval, this review aimed first elaborate under conditions then discuss clinical significance diseases according systems. Conclusions plays important a variety may used diagnostic biomarker therapeutic target for new strategies prevention treatment