Dopaminergic and serotonergic modulation of social reward appraisal in zebrafish (Danio rerio) under circumstances of motivational conflict: towards a screening test for anti-compulsive drug action.

摘要: Abstract Cognitive flexibility, shown to be impaired in patients presenting with compulsions, is dependent on balanced dopaminergic and serotonergic interaction. Towards the development of a zebrafish (Danio rerio) screening test for anti-compulsive drug action, we manipulated social reward appraisal under different contexts by means (apomorphine) (escitalopram) intervention. Seven groups (n = 6 per group) were exposed 24 days (1 h day) either control (normal tank water), apomorphine (50 or 100 μg/L), escitalopram (500 1000 μg/L) combination (A100/E500 A100/E1000 μg/L). Contextual was assessed over three phases i.e. Phase 1 (contingency association), 2 (dissociative testing), 3 (re-associative testing). We demonstrate that 1) sight conspecifics an inadequate motivational reinforcer circumstances conflict, 2) intervention lessens importance aversive stimulus, increasing valence reward, 3) while serotoninergic maintains directed behavior, high-dose bolsters cue-directed responses 4) reversed apomorphine-induced behavioral inflexibility. The results reported here are supportive current dopamine-serotonin opponency theories confirm as potentially useful species which investigate compulsive-like behaviors.