The anti-inflammatory function of high-density lipoprotein in type II diabetes: A systematic review

摘要: Background Inflammation is a pathophysiological factor in diabetes and its cardiovascular complications. High-density lipoprotein (HDL) suppresses inflammation healthy individuals. The relationship of HDL with disease may be explained by function rather than cholesterol level. In diabetes, seems to become dysfunctional. Objective We performed systematic review answer the following research questions: Is anti-inflammatory diminished individuals if so, what causes this? Methods systematically searched Medline Embase included original articles on effects or HDL-based interventions models. assessed risk bias all studies. Results Fourteen studies were included. These showed great heterogeneity methodology, study populations, Overall, from subjects type II displayed reduced ability suppress inflammatory processes markers. However, mechanisms in vivo remain largely unknown. No reported other types diabetes. most studies, was high could not assessed. Conclusions isolated decreased inflammation. direction causality underlying are unknown should investigated. For development treatments directed at restoring standardized method for assessing needs developed biomarkers must identified.