Gender Affects the Median Effective Dose and 95% Effective Dose of Oxycodone for Blunting the Hemodynamic Response to Tracheal Intubation in Narcotic-Naïve Adult Patients

摘要: Background: Intravenous (IV) oxycodone has been used at induction to prevent an intubation reaction. The aims of the current study were calculate median effective dose (ED50) and 95% (ED95) IV bolus that blunts hemodynamic response tracheal with propofol according gender observe adverse events induction-dose oxycodone. Methods: Adult patients who required general anesthesia enrolled. Tracheal was performed using unified TD-C-IV video laryngoscopy ordinary common endotracheal tube. Dixon’s up-and-down method obtain ED50 data for women men separately. initial 0.2 mg/kg 0.3 (step size 0.01 mg/kg). Next, a dose-response curve from probit analysis generated determine ED95 blunt reaction in female male patients. Adverse following injection observed 5 min before injection. Results: Sixty-three analyzed, including 29 females 34 males. According analysis, 0.254 (95% confidence interval [CI], 0.220–0.328 mg/kg) 0.357 CI, 0.297–2.563 mg/kg), respectively. In men, 0.324 0.274–0.381 0.454 0.384–2.862 Men 28% more than (P < 0.01). most dizziness (87.3%), vertigo (66.7%), sedation (74.6%), respiratory depression (66.7%). Conclusions: Oxycodone can be reactions. Gender affected blunting reaction. Key words: Adverse Events; Hemodynamics; Induction; Intubation; Oxycodone