Structural and mechanistic basis for a new mode of glycosyltransferase inhibition

摘要: Glycosyltransferases are carbohydrate-active enzymes with essential roles in numerous important biological processes. We have developed a new donor analog for galactosyltransferases that locks representative target enzyme catalytically inactive conformation, thus almost completely abolishing sugar transfer. Results other suggest this unique mode of glycosyltransferase inhibition may also be generally applicable to members family.