Ribosomal DNA and cellular senescence: new evidence supporting the connection between rDNA and aging.

摘要: The yeast Saccharomyces cerevisiae is a powerful model system to understand the molecular basis of aging. It has been known for over 50 years that cells have finite replicative capacity and develop an aging phenotype, much recent research focused on changes underlie this senescence. A common thread in many studies involvement ribosomal DNA gene repeats (rDNA), beginning with discovery rDNA silencing gene, SIR2, regulates life span. In 2008, novel hypothesis, termed theory aging, was presented where high level genomic instability at proposed dominate global genome stability determine Here, we review discuss number provide important new data roles Based these results, propose integrative encompasses instability, chromatin relocalization following repair, replication stress self-reinforcing cyclical pathway primarily manifested results phenotype.