G protein coupled receptors signaling pathways implicate in inflammatory and immune response of rheumatoid arthritis

摘要: G protein-coupled receptors (GPCRs) are transmembrane receptor proteins, which allow the transfer of signals across membrane. Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovitis and accompanied with inflammatory abnormal immune response. GPCRs signaling pathways play a significant role in response processes including RA. In this review, we have focused on advances pathway implicating The GPCRs–adenylyl cyclase (AC)–cyclic adenosine 3′, 5′-monophosphate (cAMP) include β2 adrenergic (β2-ARs)–AC–cAMP pathways, E-prostanoid2/4 (EP2/4)–AC–cAMP so on. Regulatory such as kinases (GRKs) β-arrestins, important modulatory roles pathway. regulatory proteins implicate pathogenesis process GPCRs–AC–cAMP signal involve Different mediated different receptors, β2-AR, PGE2 receptor, chemokines receptor. GRKs β-arrestins crucial regulation pathways. potential therapeutic targets well strategies to modulate new development trends.