Role of exposure to environmental chemicals in the developmental basis of reproductive disease and dysfunction.

摘要: There is a paradigm shift in science at present that indicates the onset of many diseases, including reproductive diseases and dysfunctions, are already programmed utero or early postnatal period. This new field called developmental basis health disease. Although focus has been on role nutrition its effects subsequent adult-onset it clear exposure to environmental stressors/toxicants during development can also increase susceptibility disease later life. The mechanism for this effect thought be altered epigenetic control gene expression, which alters programming results tissue may appear normal but functionally compromised. concept still hypothesis, review addresses current state data relating proving importance diseases. If shown true, then examination etiology prevention intervention strategies will need modified fit paradigm.