Nonparametric Estimation of the Hazard Ratio

摘要: Abstract A nonparametric estimate of the hazard ratio function is developed and applied to time-dependent survival advantage having achieved an objective response treatment for a given disease. The method computes total exposure risk failure, or dying, among patients in either two disease states (nonresponder/responder). By assuming constant rates between observed failure times, using smoothing techniques exploratory data analysis, log computed plotted versus time. applicable any binary, covariate, which state particular example. Continuous-valued covariates may be handled by plot updated covariate percentiles failures. methods are on leukemia simulated example compared with standard Cox regression results.