Use of intraoperative sodium fluorescein for diagnostic tissue biopsy of spinal cord lesions

摘要: Abstract Background Recent evidence suggests that fluorescein-guided microsurgery facilitates resection of intrinsic and metastatic lesions in the brain. Use sodium fluorescein for angiography has previously been reported without non-specific diffusion into adjacent spinal parenchyma. Diagnostic biopsy cord lesion is often challenging localization such intraoperatively paramount. We present first known report use diagnostic lesions. Methods Three patients with received 10% (Alcon Laboratories INC, Fort Worth, TX, USA) at 3 mg/kg prior to surgical resection. Intraoperative visualization fluorescence was performed using a Zeiss Pentero (Carl AG, Oberkochen, Germany) microscope equipped Yellow560 filter or Leica OH6 (Leice Microsystems, Wetzlar, FL560 filter. Results Administration resulted lesional fluorescent contrast extravasation facilitated The addition allowed identification three patients. In undergoing biopsy, tissue samples were positive pathology. Conclusion Fluorescein may be helpful microsurgical tool guiding intramedullary Further research necessary explore applications