Functional discrimination by human monocytes between their C3b receptors and their recognition units for particulate activators of the alternative complement pathway.

摘要: A trypsin-sensitive recognition unit for ingestion of particulate activators the human alternative complement pathway is present on monocytes and persists during 48 hr culture in synthetic medium. Further, after inactivation by trypsin, fully regenerated terms function culture. In contrast, C3b receptor relatively trypsin resistant lost culture, as assessed its capacity to mediate C3b-dependent immune adherence or enhanced phagocytosis. The prior C3b-bearing particles does not alter ingest a activator, induce phagocytosis rosetted particles. Thus, functions linked are expressed independently when determinants reside separate When same particle, such an activator bearing C3b, exhibit synergistic response through their distinct units pathway.