Top-down and bottom-up visual information processing of non-social stimuli in high-functioning autism spectrum disorder

摘要: Abstract Individuals with high-functioning autism spectrum disorder (HF-ASD) often show superior performance in simple visual tasks, despite difficulties the perception of socially important information such as facial expression. The neural basis abnormalities associated HF-ASD is currently unclear. We sought to elucidate functioning bottom-up and top-down processing using event-related potentials (ERPs). Eleven adults 11 age-matched normal controls (NC) participated this study. Visual ERPs were recorded 128-channel EEG. P1 P300 response target stimuli. mismatch negativity (vMMN) obtained by subtracting responses standard from those deviant Behaviorally, individuals showed faster detection than NCs. However, vMMN amplitude latency same between two groups. In contrast, amplitudes significantly decreased compared addition, was delayed HF-ASD. exhibit altered processing. Intact attention may contribute their task spite abnormal low-level (P1) (P300)