β-Glycerol phosphate/genipin chitosan hydrogels: A comparative study of their properties and diclofenac delivery.
作者： Sheila Maiz-Fernández , Olatz Guaresti , Leyre Pérez-Álvarez , Leire Ruiz-Rubio , Nagore Gabilondo
DOI: 10.1016/J.CARBPOL.2020.116811
关键词:
摘要: Abstract Thermosensitive hydrogels based on polysaccharides are suitable candidates for the design of biodegradable and biocompatible injectable drug delivery systems. Thus, combination chitosan (CHI) β-glycerol phosphate disodium salt (β-GP) has been intensively investigated to develop thermo-induced physical gels. With aim exploring possibilities optimization these hydrogels, in this work, chitosan, β-GP naturally extracted crosslinking agent, genipin (GEN), have successfully combined, obtaining co-crosslinked with both situ covalent crosslinking. A wide range concentrations selected order analyze its influence a variety properties, including gelation time, pore size, water uptake ability, vitro hydrolytic enzymatic degradation, mucoadhesion mechanical rheological properties. Furthermore, potential application developed systems administration controlled release an anti-inflammatory anionic drug, such as diclofenac, demonstrated.
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