Side-Chain Peptide-Synthetic Polymer Conjugates via Tandem "Ester-Amide/Thiol-Ene" Post-Polymerization Modification of Poly(pentafluorophenyl methacrylate) Obtained Using ATRP
作者： Nikhil K Singha , Matthew I Gibson , Bishnu P Koiry , Maarten Danial , Harm-Anton Klok
DOI: 10.1021/BM200469A
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摘要: Herein the concept of tandem postpolymerization modification as a versatile route to synthesize well-defined, highly functionalized polymers is introduced. Poly(pentafluorophenyl methacrylate) obtained by atom transfer radical polymerization was first modified with allylamine, which displaces active ester give well-defined pendant alkene groups, are difficult obtain direct (radical) allylic-functional monomers. The produced poly(allylmethacrylamide) second reaction thiol-terminated peptide (CVPGVG) using AIBN source. NMR, IR, and SEC demonstrated successful conjugation onto polymer polymer–peptide hybrid material. This strategy should extend scope controlled “click”-type reactions
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