Neuropsychological and Renal Effects of Dental Amalgam in Children

摘要: ContextNo randomized trials have been published that address the concern inhalation of mercury vapor released by amalgam dental restorations causes adverse health effects.ObjectiveTo compare neuropsychological and renal function children whose caries were restored using or mercury-free materials.Design SettingThe New England Children's Amalgam Trial was a 2-group safety trial involving 5 community clinics in Boston, Mass, 1 Farmington, Me, between September 1997 March 2005.Participants InterventionA total 534 aged 6 to 10 years at baseline with no prior 2 more posterior teeth randomly assigned receive restoration incident during 5-year follow-up period either (n=267) resin composite (n =267) materials.Main Outcome MeasuresThe primary outcome change full-scale IQ scores. Secondary outcomes included tests memory visuomotor ability. Renal glomerular measured creatinine-adjusted albumin urine.ResultsChildren had mean 15 tooth surfaces (median, 14) (range, 0-55). Assignment group associated significantly higher urinary level (0.9 vs 0.6 μg/g creatinine year 5, P<.001). After adjusting for randomization stratum other covariates, statistically significant differences found groups score (3.1 2.1, P = .21). The difference treatment scores 1.0 (95% confidence interval, −0.6 2.5) point. No 4-year general index (8.1 7.2, P = .34), (3.8 3.7, P = .93), 7.5 7.4 mg/g creatinine, P = .61).ConclusionsIn this study, there effects observed over materials. Although it is possible very small cannot be ruled out, these findings suggest need not basis decisions when choosing restorative materials.Trial Registrationclinicaltrials.gov Identifier: NCT00065988