Delayed Graft Function and Kidney Transplantation

摘要: Delayed graft function (DGF), most commonly defined as the need for dialysis in first 7 days post-transplant, continues to be a common problem modern era of kidney transplantation. Multiple complex biochemical and structural changes occur at cellular level result ischemia reperfusion injury allograft, which predispose recipients DGF. Several transplant, donor, recipient factors have been found associated with an increased risk This chapter will provide overview these well practical approach clinical evaluation A number preventive therapeutic interventions such use certain preservation solutions, pulsatile machine perfusion, vasodilatory drugs, immunosuppressive agents extensively studied variable results. These interventions, quality evidence supporting their use, also reviewed. Finally, this highlight short- long-term consequences DGF, particular emphasis on association between survival, death function.